Figure 7.

Antibody recognition of the original SARS-CoV-2 RBD predicts binding efficacy to the evolved variants. Predictive correlation analyses of (A,B) anti-RBD IgG and (C,D) anti-RBD IgA antibodies against distinct RBD variants of SARS-CoV-2, as determined by the FCCA, grouped according to the convalescent ± vaccinated cohorts (A,C), and vaccinated-only cohorts (B,D). RBD reactivity of antibodies against the original Wuhan-Hu-1 strain was used as the predictor on the x-axes. Each symbol corresponds to a distinct sample. Coefficient of determination, r², and the linear regression line (black) are indicated on each graph.