Probability of T2DM development by COX analysis according to the tertiles of ΔNRF9.3. (A) unadjusted model. (B) adjusted model controlled for sex, statins, age, BMI, LDL, smoking habits, HDL, TG. C fully adjusted model controlled for sex, statins, age, BMI, LDL, smoking habits, HDL, TG., HOMA-IR, ISI, DI and IGI. Reference was the Tertile 1 (lowest). The hazard ratio (HR) between groups was calculated. Abbreviation: BMI, Body mass index; LDL, Low-density lipoprotein; HDL, high-density lipoprotein; TG, Tryglicerides, HOMA-IR, homeostatic model assessment; ISI, insulin sensitivity index; DI, disposition index; IGI, insulinogenic index. * p < 0.05.