Figure 7.

Schematic diagram of the potential mechanism by which Faecalibacterium prausnitzii ameliorates intestinal injury induced by sleep deprivation. A feasible mechanism is that the colonization of Faecalibacterium prausnitzii ameliorates impaired intestinal barrier function in SD mice through regulating intestinal inflammation, programmed death, and the gut microbiota. SD: sleep deprivation; LPS: lipopolysaccharide; ZO-1: tight-junction protein zonula occluden-1; TNF-α: tumor necrosis factor-alpha; IL-6; interleukin-6. (+); promote; (-); inhibit.