Figure 8.

Schematic structure of DGR cassettes found in the genomes of crAssE-Sib and other members of the Epsilonunovirus genus. Schematic structure of DGR cassettes found in the genomes of crAssE-Sib and other members of the Epsilonunovirus genus. DGRs contain the receptor binding protein (RBP—green arrow) and reverse transcriptase (RT—red arrow) genes as well as template repeat (TR—light blue) with IMH* sequence (orange) and variable repeat (VR—blue) with initiation of the mutagenic homing (IMH—yellow) sequence. RT is fragmented or absent in many Epsilonunoviruses. Empty arrows indicate hypothetical proteins.