Table 3.
Average percentage composition of statistically significant intestinal microbiota families in CRC-induced animals for the four cohorts studied. Underlined families indicate significant differences (ANOVA test) between at least one of the cohorts treated with flavonoids (Cohorts 2, 3, and 4) and the control cohort (Cohort 1). Percentages marked with asterisks indicate that the cohort shows a statistically significant difference compared to the control cohort within a specific family, along with the corresponding level of statistical significance. Cohort 1: PBS administration; Cohort 2: quercetin administration; Cohort 3: luteolin administration; Cohort 4: xanthohumol administration. Asterisks indicate statistically significant differences (* p < 0.05; ** p < 0.005; *** p < 0.0005; **** p < 0.0001).
| Cohort 1 (%) | Cohort 2 (%) | Cohort 3 (%) | Cohort 4 (%) | |
|---|---|---|---|---|
| Eggerthellaceae | 0.24 | 0.16 | 0.05 **** | 0.18 |
| Bacteroidaceae | 5.26 | 4.21 | 5.42 | 6.12 |
| Muribaculaceae | 15.50 | 16.42 | 14.61 | 14.61 |
| Prevotellaceae | 6.83 | 7.93 | 11.09 **** | 10.80 **** |
| Rikenellaceae | 2.76 | 2.34 | 3.40 | 2.38 |
| Tannerellaceae | 1.63 | 1.49 | 1.49 | 1.88 |
| Gastranaerophilales | 0.27 | 0.34 | 0.69 | 1.06 ** |
| Deferribacteraceae | 0.31 | 0.34 | 0.43 | 0.19 |
| Desulfovibrionaceae | 0.53 | 0.43 | 0.95 | 0.60 |
| Acholeplasmataceae | 0.30 | 0.17 | 0.15 | 0.14 |
| Bacillaceae | 0.85 | 0.53 | 0.49 | 0.30 |
| Erysipelatoclostridiaceae | 0.17 | 0.05 | 0.04 | 0.24 |
| Erysipelotrichaceae | 0.82 | 0.60 | 0.13 *** | 0.43 |
| Lactobacillaceae | 2.93 | 3.20 | 2.35 | 2.97 |
| RF39 (Bacillota) | 0.25 | 0.29 | 0.11 | 0.24 |
| Christensenellaceae | 0.77 | 0.28 | 0.09 **** | 0.67 |
| Clostridia UCG-014 | 4.37 | 3.64 | 1.88 | 4.94 |
| Clostridia vadin BB60 group | 0.19 | 0.09 | 0.88 * | 0.11 |
| Lachnospiraceae | 26.07 | 27.94 | 24.93 | 21.84 |
| Monoglobaceae | 0.25 | 0.23 | 0.20 | 0.13 |
| Butyricicoccaceae | 0.23 | 0.26 | 0.61 ** | 0.37 |
| Oscillospiraceae | 13.11 | 13.43 | 15.38 | 13.48 |
| Ruminococcaceae | 11.36 | 10.31 | 10.86 | 10.80 |
| Oscillospirales UCG-010 | 0.21 | 0.18 | 0.25 | 0.22 |
| Coprostanoligenes group | 1.26 | 1.06 | 0.67 | 1.09 |
| Peptococcaceae | 0.72 | 0.65 | 0.52 | 0.62 |
| Anaerovoracaceae | 0.26 | 0.16 | 0.10 **** | 0.16 |
| Peptostreptococcaceae | 0.58 | 0.21 | 0.25 | 0.53 |
| Saccharimonadaceae | 0.35 | 2.06 * | 1.07 | 1.28 * |
| Uncultured (Rhodospirillales) | 0.03 | 0.02 | 0.17 | 0.22 |
| Sutterellaceae | 0.01 | 0.02 | 0.03 | 0.16 *** |
| Enterobacteriaceae | 0.69 | 0.07 * | 0.08 * | 0.31 |
| Moraxellaceae | 0.00 | 0.00 | 0.00 | 0.12 |
| Akkermansiaceae | 0.62 | 0.67 | 0.48 | 0.52 |