Figure 3.

Immunisation with GAS conjugate vaccines does not reduce colonisation or signs in infected NHPs. Individual scores for colonisation (A), pharyngitis (B) and tonsillitis (C) following infection of immunised NHPs with 5 × 10⁷ CFU of GAS M1T1 5448. Individual NHP identifiers are indicated on the left. Log rank analysis of grouped cumulative scores for colonisation (D), pharyngitis (E) and tonsillitis (F) following GAS infection was performed to compare protection conferred by immunisation with J8-ADI (pink lines) and ΔGAC-ADI (green lines) to that of PBS-immunised control NHPs (black lines). Cumulative scores observed in a previously reported study [18] for PBS (black lines) and M1 (red lines) immunised NHPs are shown for comparative purposes. Values represent cumulative score percentages ± SE.