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. 2024 Apr 8;16(4):514. doi: 10.3390/pharmaceutics16040514

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Morphological evaluation of H&E-stained sections in the CA1, CA2, CA3, CA4, and dentate gyrus regions of the hippocampus in diabetic Parkinson’s disease (DP) rats. Control rats (A–E) display normal neuron cells (arrow). Vehicle-treated DP rats (F–J) exhibit neuron cells (arrow) alongside highly condensed pyknotic nuclei (head arrow) and pericellular haloes (asterisk). CBD-treated DP rats (K–O) also show normal neuron cells (arrow). CBD-LNP-treated DP rats (P–T) reveal numerous normal neuron cells (arrow) with reduced pyknotic nuclei (head arrow) and pericellular haloes (asterisk). Levodopa-treated DP rats (U–Y) display normal neuron cells (arrow) along with pyknotic nuclei (head arrow) and pericellular haloes (asterisk). Scale bars represent 50 µm (magnification, 40×). PCL, pyramidal cell layer; GCL, granule cell layer.