Figure 8.

The antidepressant mechanism of the Polygonati Rhizoma extract DFV in a BV-2 cell model by inhibiting COX2-mediated inflammatory response (created with BioRender.com, accessed on 12 March 2024). In BV-2 cells, LPS promotes the gene expression and protein translation of COX2 by binding to receptors, further promoting the gene and protein expression of NLRP3, leading to the release of inflammatory factors such as IL-1 β, IL-6, and TNF-α. The inflammatory environment causes the accumulation of reactive oxygen species (ROS), which damages mitochondria, manifested as a decrease in mitochondrial membrane potential. ROS promotes the accumulation of oxidative product MDA, which exacerbates mitochondrial damage. SOD prevents and repairs this damage process. On the other hand, NLRP3 promotes the hydrolysis and cleavage of caspase1, further inducing the release of activated IL-1 β and triggering neuroinflammation. The compound DFV in Polygonati Rhizoma reduced the gene expression and protein translation of COX2 by binding to it, thereby preventing subsequent inflammatory reactions.