Table 4.

Micronucleus assay: four-hour treatment with metabolic activation to assess cytotoxicity.

Treatment (µg/mL)	Cytotoxicity RICC (%)	MN (%)	z′
10% Sucrose (2.6%)	0	0.89	NA
CP 4.7 µg/mL	50	5.58	0.79 *
CP 11.9 µg/mL	82	15.58	0.91 *
PolySia-NP
31.3	−5	0.51	<0
62.5	−12	0.51	<0
125	−14	0.58	<0
250	−18	1.4	<0
500	3	0.3	0.24

MN: Micronucleated Cells, NA: Not applicable. CP: Cyclophosphamide Monohydrate. RICC: Relative Increase in cell count. * z′ ≥ 0.6.