Table 5.
Repeat micronucleus assay: four-hour treatment without metabolic activation to assess cytotoxicity.
| Treatment (µg/mL) | Cytotoxicity RICC (%) | MN (%) | z′ |
|---|---|---|---|
| 10% Sucrose (2.6%) | 0 | 0.3 | NA |
| MMC 0.0625 µg/mL | 50 | 3.47 | 0.78 * |
| MMC 0.125 µg/mL | 63 | 8.7 | 0.88 * |
| PolySia-NP | |||
| 31.3 | 0 | 0.3 | a |
| 62.5 | −10 | 0.26 | <0 |
| 125 | −2 | 0.42 | <0 |
| 250 | −23 | 0.39 | <0 |
| 500 | −4 | 0.35 | <0 |
MN: Micronucleated Cells, NA: Not applicable. RICC: Relative Increase in cell count. MCC: Mitomycin C. * z′ ≥ 0.6. a Not calculated if Mean MN is the same as Vehicle Control.