Table 6.

Micronucleus assay: twenty-seven-hour treatment without metabolic activation.

Treatment (µg/mL)	Cytotoxicity RICC (%)	MN (%)	z′
10% Sucrose (2.6%)	0	0.37	NA
VIN 2.5 ng/mL	46	4.19	0.79 *
VIN 3.0 ng/mL	57	5.4	0.83 *
PolySia-NP
31.3	−6	0.29	<0
62.5	−2	0.32	<0
125	−3	0.28	<0
250	3	0.36	<0
500	1	0.37	<0

MN: Micronucleated Cells. NA: Not applicable. VIN: Vinblastine Sulfate. * z′ ≥ 0.6. RICC: Relative Increase in cell count.