Table 8.
Summary of Microscopic Findings–Terminal Euthanasia (Day 29) | ||||||||
---|---|---|---|---|---|---|---|---|
Males | Females | |||||||
Group | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 |
Dose (mg/eye) | 0 | 0.05 | 0.15 | 0.5 | 0 | 0.05 | 0.15 | 0.5 |
No. Animals per Group | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
Eyes (No. Examined) | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
Right: Infiltration, mononuclear cell, vitreous chamber |
(0) a | 0 | 2 | 3 | 0 | 0 | 2 | 3 |
Minimal Mild | 0 | 0 | 2 | 1 | 0 | 0 | 2 | 1 |
Mild | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 |
Left: Infiltration, mononuclear cell, vitreous chamber |
0 | 0 | 3 | 3 | 0 | 0 | 2 | 3 |
Minimal | 0 | 0 | 3 | 1 | 0 | 0 | 2 | 2 |
Mild | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 |
a Numbers in parentheses represent the number of animals with the finding | ||||||||
Summary of Microscopic Findings–Recovery Euthanasia (Day 43) | ||||||||
Males | Females | |||||||
Group | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 |
Dose (mg/eye) | 0 | 0.05 | 0.15 | 0.5 | 0 | 0.05 | 0.15 | 0.5 |
No. Animals per Group | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
Eyes (No. Examined) | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
Right: Infiltration, mononuclear cell, vitreous chamber |
(0) a | 0 | 1 | 2 | 0 | 0 | 1 | 2 |
Minimal Mild | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Mild | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Left: Infiltration, mononuclear cell, vitreous chamber |
0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 |
Minimal | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 |
Mild | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
a Numbers in parentheses represent the number of animals with the finding |