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Host interferon responses to SARS-CoV-2 infection. Colonoid lines in 2D transwell monolayers derived from four donors were infected with indicated SARS-CoV-2 variants at an MOI of 0.01. RNA was harvested 24 h post infection and levels of IFNL3 (A), IFNB (B), and MX1 (C) were quantified by RT-qPCR and normalized to GAPDH (mean with SEM).
