Table 1.
Distribution of patient characteristics at diagnosis by disease stage and associated adjusted odds ratios for late versus early-stage CRC presentation
| Characteristics | Early-stage N (%) |
Late-stage N (%) |
OR (95%CI) | ||
|---|---|---|---|---|---|
| 12,402 (70.7) | 5,139 (29.3) | ||||
| Age in yrs, mean (SD) | 57.93 (14.8) | 57.81 (14.9) | |||
| Age group in yrs | 0–39 | 1383 (11.2) | 598 (11.6) | 1.10 (0.99, 1.22) | |
| 40–49 | 2103 (17.0) | 936 (18.2) | 1.13 (1.03, 1.23) | ||
| 50–59 | 3113 (25.1) | 1222 (23.8) | 1.00 P = 0.01 | ||
| 60–69 | 2941 (23.7) | 1170 (22.8) | 1.03 (0.93, 1.12) | ||
| 70–79 | 2013 (16.2) | 859 (16.7) | 1.11 (1.00, 1.21) | ||
| 80+ | 843 ( 6.8) | 353 ( 6.9) | 1.09 (0.95, 1.23) | ||
| Sex | Male | 6930 (55.9) | 2713 (52.8) | 1.00 P < 0.001 | |
| Female | 5472 (44.1) | 2426 (47.2) | 1.12 (1.06, 1.19) | ||
| Marital status | Married | 10,020 (89.9) | 4169 (88.0) | 1.00 P < 0.01 | |
| Unmarried | 1126 (10.1) | 568 (12.0) | 1.09 (0.98, 1.19) | ||
| Region | Riyadh | 3787 (30.8) | 1583 (31.1) | 1.00 P < 0.0001 | |
| Eastern | 2031 (16.5) | 961 (18.9) | 1.13 (1.03, 1.23) | ||
| Makkah | 3150 (25.6) | 1200 (23.6) | 0.91 (0.83, 1.00) | ||
| Madina | 705 ( 5.7) | 235 ( 4.6) | 0.81 (0.65, 0.96) | ||
| Asir | 911 ( 7.4) | 346 ( 6.8) | 0.91 (0.77, 1.05) | ||
| Jazan | 239 ( 1.9) | 77 ( 1.5) | 0.77 (0.51, 1.04) | ||
| Najran | 115 ( 0.9) | 53 ( 1.0) | 1.09 (0.76, 1.42) | ||
| Hail | 224 ( 1.8) | 108 ( 2.1) | 1.15 (0.91, 1.39) | ||
| Qassim | 564 ( 4.6) | 250 ( 4.9) | 1.06 (0.90, 1.22) | ||
| Baha | 198 ( 1.6) | 57 ( 1.1) | 0.68 (0.38, 0.98) | ||
| Jouf | 86 ( 0.7) | 59 ( 1.2) | 1.63 (1.30, 1.97) | ||
| Northern | 67 ( 0.5) | 45 ( 0.9) | 1.59 (1.21, 1.98) | ||
| Tabuk | 237 ( 1.9) | 118 ( 2.3) | 1.18 (0.95, 1.41) | ||
| Diagnosis date | 1997–2001 | 1112 ( 9.0) | 348 ( 6.8) | 1.00 P < 0.0001 | |
| 2002–2006 | 2054 (16.6) | 823 (16.0) | 1.28 (1.14, 1.43) | ||
| 2007–2011 | 3336 (26.9) | 1492 (29.0) | 1.43 (1.30, 1.57) | ||
| 2012–2017 | 5900 (47.6) | 2476 (48.2) | 1.34 (1.21, 1.47) | ||
| Anatomical site | Colon | 7513 (60.6) | 3027 (58.9) | 1.00 P < 0.01 | |
| Rectosigmoid | 1847 (14.9) | 873 (17.0) | 1.17 (1.08, 1.27) | ||
| Rectal | 3042 (24.5) | 1239 (24.1) | 1.01 (0.93, 1.09) | ||
Note: CI: Confidence interval; N: Number; OR: Odds ratios adjusted for all factors in the table using complete stage data and multiple imputation of covariates; SD: Standard deviation. The p-values are derived from the overall likelihood ratio tests for association. Number and percentage of missing values relative to the dataset with known cancer stage: Age at diagnosis (n = 7, 0.04%); Marital status (n = 1658, 9.5%); Geographical region (n = 135, 0.8%). Percentages are presented by column to characterise patients’ profiles for patients with late-stage and early-stage CRC