Table 3.

Adjusted odds ratios for late versus early-stage CRC presentation, by region and sex

Characteristics	Group (A) regions (N = 10,370)		Group (B) regions (N = 7,171)
	Males (N = 5,658)	Females (N = 4,712)	Males (N = 3,985)	Females (N = 3,186)
	OR (95%CI)	OR (95%CI)	OR (95%CI)	OR (95%CI)
Age group in yrs
0–39	0.95 (0.73, 1.17)	1.34 (1.14, 1.55)	0.95 (0.67, 1.23)	1.12 (0.84, 1.39)
40–49	1.02 (0.83, 1.20)	1.32 (1.14, 1.50)	1.11 (0.88, 1.34)	1.05 (0.81, 1.29)
50–59	1.00 P = 0.22	1.00 P < 0.01	1.00 P = 0.01	1.00 P = 0.02
60–69	1.01 (0.84, 1.18)	1.09 (0.91, 1.27)	0.87 (0.66, 1.08)	1.10 (0.88, 1.33)
70–79	1.11 (0.93, 1.28)	1.11 (0.90, 1.33)	1.10 (0.88, 1.32)	0.94 (0.69, 1.20)
80+	1.13 (0.88, 1.37)	1.09 (0.80, 1.38)	1.23 (0.95, 1.52)	0.63 (0.26, 1.01)
Marital status
Married	1.00 P = 0.85	1.00 P = 0.02	1.00 P = 0.30	1.00 P = 0.38
Unmarried	1.07 (0.82, 1.31)	1.25 (1.09, 1.42)	1.23 (0.97, 1.49)	1.19 (0.99, 1.40)
Diagnosis date
1997–2001	1.00 P < 0.0001	1.00 P = 0.02	1.00 P = 0.06	1.00 P < 0.0001
2002–2006	1.16 (0.90, 1.42)	1.18 (0.91, 1.45)	1.40 (1.08, 1.71)	1.81 (1.44, 2.18)
2007–2011	1.56 (1.32, 1.80)	1.39 (1.14, 1.64)	1.20 (0.90, 1.50)	1.85 (1.50, 2.19)
2012–2017	1.34 (1.11, 1.57)	1.28 (1.05, 1.52)	1.13 (0.84, 1.42)	2.07 (1.73, 2.41)
Anatomical site
Colon	1.00 P = 0.47	1.00 P < 0.01	1.00 P = 0.04	1.00 P = 0.92
Rectosigmoid	1.09 (0.93, 1.25)	1.34 (1.16, 1.51)	1.29 (1.09, 1.49)	0.98 (0.76, 1.20)
Rectal	0.99 (0.85, 1.12)	1.04 (0.89, 1.19)	0.98 (0.86, 1.15)	1.06 (0.86, 1.26)

Note: CI: Confidence interval; N: Number; OR: Odds ratios adjusted for all factors in the table using complete stage data and multiple imputation of covariates. The p-values are derived from the overall likelihood ratio tests for association