TABLE 1.

Infectivity of SNV-derived anti-Her2neu scA-displaying retroviral vector particles on various cell lines^a

Source of SNV vector particles	Virus titer (CFU/ml)
	D17	COLO-320DM	SK-BRK-3	MDA-MB453	HeLa	293	HT1080	A431
DSH	106	3 × 101	<101	<101	<101	<101	<101	<101
gp13 + AJ7	<100	2 × 104	6 × 103	5 × 103	5 × 103	6 × 103	<100	<100
DSH + AJ7	106	2 × 105	104	105	5 × 104	2 × 104	<101	<101

^aD17 cells are dog cells that can be efficiently infected with wild-type SNV vector particles (e.g., virus harvested from DSH helper cells). gp13-AJ7 and DSH-AJ7 cells are stable packaging cells producing vector particles that display anti-Her2neu scAs on the viral surface without and with the wild-type SNV envelope, respectively. All human cell lines except HT1080 or A431 express Her2neu. Because HT1080 and A431 cells do not express Her2neu, they cannot be infected with SNV vector particles that display anti-Her2neu scAs.