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. 2024 Apr 12;14:1375697. doi: 10.3389/fonc.2024.1375697

Table 3.

PICU Survival for Patients Not Treated with Intrapulmonary FVIIa.

Variable Total (n=18) Survived ICU (n=7) Died ICU
(n=11)
P Value
Age (years) 0.196
 N 18 7 11 .
 Mean (SD) 10.4 (6.3) 12.9 (6.1) 8.9 (6.1) .
 Median (Range) 11.5 (0.8~20.0) 13.0 (1.0~20.0 10.0 (0.8~19.0 .
Gender 0.627
 Female 12 (66.7%) 4 (57.1%) 8 (72.7%) .
 Male 6 (33.3%) 3 (42.9%) 3 (27.3%) .
Primary Diagnosis 0.137
 Brain tumor 1 (5.6%) 1 (14.3%) .
 Non-malignant Hematologic disorder 1 (5.6%) 1 (9.1%) .
 Leukemia 14 (77.8%) 4 (57.1%) 10 (90.9%) .
 Primary HLH 1 (5.6%) 1 (14.3%) .
 Solid tumor 1 (5.6%) 1 (14.3%) .
Post HCT 0.881
 No 3 (16.7%) 1 (14.3%) 2 (18.2%) .
 Autologous 1 (5.6%) 1 (14.3%) .
 MUD 5 (27.8%) 2 (28.6%) 3 (27.3%) .
 Haploidentical 9 (50.0%) 3 (42.9%) 6 (54.5%) .
Diagnosis Pulmonary Hemorrhage 1.000
 BAL 11 (61.1%) 4 (57.1%) 7 (63.6%) .
 Clinical 7 (38.9%) 3 (42.9%) 4 (36.4%) .
OSI, pre 1.000
 N 12 5 7 .
 Mean (SD) 18.2 (15.8) 17.4 (13.4) 18.7 (18.3) .
 Median (Range) 11.4 (4.5~58.8) 11.5 (4.5~38.8) 11.3 (5.6~58.8) .
OI, pre NA
 N 4 1 3
 Mean (SD) 23.3 (13.8) 2.6 (NA) 30.2 (1.6)
 Median (Range) 29.25 (2.6, 32.0) 29.5 (29.0, 32.0)
PICU LOS, days 0.093
 N 18 7 11 .
 Mean (SD) 26.9 (26.4) 15.6 (11.4) 34.2 (31.0) .
 Median (Range) 18.5 (1.0~93.0) 11.0 (3.0~36.0) 23.0 (1.0~93.0) .
Hospital LOS, days 0.348
 N 18 7 11 .
 Mean (SD) 46.6 (31.6) 37.6 (30.2) 52.4 (32.5) .
 Median (Range) 34.5 (3.0~109.0) 29.0 (3.0~99.0) 46.0 (4.0~109.0) .
Vent free days 0.004
 N 18 7 11 .
 Mean (SD) 6.1 (9.6) 15.6 (9.3) 0.0 (0.0) .
 Median (Range) 0.0(0.0~25.0) 19.0(3.0~25.0 0.0(0.0~0.0) .
PLT count 0.770
 N 18 7 11 .
 Mean (SD) 64.3 (35.6) 68.1 (52.2) 61.8 (22.6) .
 Median (Range) 64.5 (8~130) 81 (8~130) 62 (32~112) .
PT 0.295
 N 18 7 11 .
 Mean (SD) 17.4 (3.7) 18.6 (4.0) 16.7 (3.4) .
 Median (Range) 16.5 (13.0~24.9) 17.7 (14.3~24.9) 15.5 (13.0~22.5) .
PTT 0.406
 N 17 7 10 .
 Mean (SD) 53.4 (26.2) 44.7 (17.0) 59.6 (30.5) .
 Median (Range) 41.2 (25.1~101.0) 41.1(27.9~76.0) 46.1 (25.1~101.0) .
INR 0.365
 N 18 7 11 .
 Mean (SD) 1.5 (0.4) 1.6 (0.5) 1.5 (0.4) .
 Median (Range) 1.4 (1.1~2.3) 1.5 (1.2~2.3) 1.3 (1.1~2.2) .
Fibrinogen 0.934
 N 17 6 11 .
 Mean (SD) 351.4 (182.3) 346.2 (148.5) 354.2 (205.2) .
 Median (Range) 381 (67~646) 388.5 (96~511) 317 (67~646) .

ICU, intensive care unit; HCT, hematopoietic cell transplant; auto, autologous; haplo, haploidentical; MSD, matched sibling donor; MUD, matched unrelated donor; BAL, bronchoalveolar lavage; OSI, oxygenation saturation index; OI, oxygenation index; SD, standard deviation; LOS, length of stay; Vent, ventilator; PLT, platelet; PT, prothrombin time; PTT, partial thromboplastin time; INR, internationalized standard ratio.