KEY RESOURCES TABLE
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Biological samples | ||
| DNA isolated from blood of COVID-19 patients | Brigham and Women’s Hospital Crimson Core | |
| Critical commercial assays | ||
| Infinium MethylationEPIC v2.0 Kit | Illumina | 20087709 |
| DNeasy Blood & Tissue Kit | Qiagen | 69504 |
| QIAamp DNA Blood Mini Kit | Qiagen | 51104 |
| RNAqueous Total RNA Isolation Kit | Invitrogen | AM1912 |
| Deposited data | ||
| Sadahiro et al., 2020 DNAm data | GEO | GSE142536 |
| Guintivano et al., 2014 DNAm data | GEO | GSE44132 |
| Emory Pregnancy Cohort DNAm data | GEO | GSE107459 |
| Born into Life Cohort DNAm data | Prof. C. Almqvist | |
| White at al, 2012 DNAm data | GEO | GSE37722 |
| Parabiosis data: HorvathMammalMethyl40 array DNAm, RRBS DNAm, and RNA-seq data | This study | GSE224447 |
| Longitudinal mouse pregnancy DNAm data | This study | GSE224352 |
| Longitudinal DNAm data for patients with severe COVID-19 | This study | GSE226206 |
| Experimental models: Organisms/strains | ||
| C57Bl/6J mice | Jackson Laboratory | 000664 |
| Software and algorithms | ||
| Prism | Graphpad | v9 |
| R | r-project.org | v4.1.1 |
| RStudio | Rstudio.com | V1.4.1717 |
| minfi package | Bioconductor | 10.18129/B9.bioc.minfi |
| SeSAMe package | Bioconductor | 10.18129/B9.bioc.sesame |
| DunedinPACE package | Github | https://github.com/danbelsky/DunedinPACE |
| PC-Clocks package | Github | https://github.com/MorganLevineLab/PC-Clocks |
| Data underlying all plots | This study | Data S1 |