Comparison 3. Quinine versus a quinine‐vitamin E combination (Q‐Vel).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Difference in number of cramps in 2 weeks ‐ random‐effects	2		No. cramps (Random, 95% CI)	1.07 [‐1.08, 3.23]
2 Difference in cramp intensity ‐ random‐effects	3		Cramp intensity (Random, 95% CI)	0.10 [‐0.06, 0.26]
3 Difference in number of cramp days over 2 weeks ‐ random‐effects	2		Cramp days (Random, 95% CI)	0.18 [‐1.13, 1.49]
4 Participants suffering minor adverse events ‐ random‐effects	3	739	Risk Difference (M‐H, Random, 95% CI)	0.03 [‐0.04, 0.10]
5 Participants suffering major adverse events ‐ fixed‐effect	3	739	Risk Difference (M‐H, Fixed, 95% CI)	‐0.00 [‐0.01, 0.01]