Table 3. Frequencies of genetic polymorphisms in BIPN and non-BIPN groups.
| Genotype | BIPNa) | non-BIPN | ORb) (95% CI) | p value |
|---|---|---|---|---|
| (n = 115) | (n = 89) | |||
| MTHFR | ||||
| rs1801131 | ||||
| TT | 68 (59.1%) | 72 (80.9%) | 1 | |
| TG | 44 (38.3%) | 17 (19.1%) | 2.74 (1.43–5.25) | 0.002 |
| GG | 3 (2.6%) | 0 (0%) | Inf | 0.12 |
| TG+GG | 47 (40.9%) | 17 (19.1) | 2.93 (1.53–5.59) | 0.001 |
| rs1801133 | ||||
| AA | 20 (17.4%) | 41 (46.1%) | 1 | |
| GG | 61 (53.0%) | 35 (39.3%) | 3.57 (1.82–7.03) | ≤0.001 |
| GA | 34 (29.6%) | 13 (14.6%) | 5.36 (2.33–12.34) | 0.001 |
| GG+GA | 95 (82.6%) | 48 (53.9%) | 4.06 (2.15–7.67) | ≤0.001 |
| rs17421511 | ||||
| GG | 80 (69.6%) | 82 (92.1%) | 1 | |
| GA | 35 (30.4%) | 7 (7.9%) | 5.13 (2.15–12.21) | ≤0.001 |
| AA | 0 (0%) | 0 (0%) | – | – |
| GA+AA | 35 (30.4%) | 7 (7.9%) | 5.13 (2.15–12.21) | ≤0.001 |
| EPHX1 | ||||
| rs1051740 | ||||
| TC | 47 (40.9%) | 50 (56.2%) | 1 | |
| CC | 11 (9.6%) | 22 (24.7%) | 0.53 (0.23–1.22) | 0.158 |
| TT | 57 (49.6%) | 17 (19.1%) | 3.57 (1.82–6.99) | ≤0.001 |
| CC+TT | 68 (59.1%) | 39 (43.8%) | 1.86 (1.06–3.25) | 0.034 |
| MME | ||||
| rs2016848 | ||||
| GG | 75 (65.2%) | 78 (87.6%) | 1 | 0.618 |
| AA | 2 (1.8%) | 1 (1.1%) | 2.08 (0.18–23.42) | |
| AG | 38 (33.0%) | 10 (11.2%) | 3.96 (1.84–8.50) | ≤0.001 |
| AG+AA | 40 (34.8%) | 11 (12.3) | 3.78 (1.81–7.92) | ≤0.001 |
| ALDH1A1 | ||||
| rs6151031 | ||||
| GCT*c)/GCT* | 101 (87.8%) | 87 (97.8%) | 1 | |
| GCT*/G | 14 (12.2%) | 2 (2.2%) | 6.03 (1.33–27.27) | 0.009 |
| G/G | 0 (0%) | 0 (0%) | – | – |
| GCT*/G+G/G | 14 (12.2%) | 2 (2.2%) | 6.03 (1.33–27.27) | 0.009 |
| HTR7 | ||||
| rs1935349 | ||||
| CC | 52 (45.2%) | 54 (60.7%) | 1 | |
| CT | 47 (40.9%) | 33 (37.1%) | 1.48 (0.82–2.66) | 0.235 |
| TT | 16 (13.9%) | 2 (2.2%) | 8.31 (1.82–37.93) | 0.002 |
| CT+TT | 63 (54.8%) | 35 (39.3%) | 1.87(1.07–3.28) | 0.034 |
| CYP2A6 | ||||
| rs8192720 | ||||
| GG | 69 (60.0%) | 61 (68.5%) | 1 | |
| AG | 31 (26.9%) | 28 (31.5%) | 0.98 (0.53–1.81) | 1 |
| AA | 15 (13.1%) | 0 (0%) | Infd) | ≤0.001 |
| AG+AA | 46 (40.0%) | 28 (31.5%) | 1.45 (0.81–2.60) | 0.241 |
Abbreviations: a): Bortezomib-induced Peripheral Neuropathy; b): odds ratios; c): GCTGGTGAGGAGAGAACC; d): infinity.