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. 2024 Jan 31;13(3):e031377. doi: 10.1161/JAHA.123.031377

Figure 3. mRNA and protein from core matrisome modifier genes found in vascular tissues.

Figure 3

A, Clustering of log2 transformed expression of the 74 core matrisome genes in 37/54 human tissues (the expression in the 15 brain tissues, cell‐EBV, and whole blood are not shown to improve visibility of the remaining 37 tissue names) from GTEX v8 database reveals 3 tiers of expression: Tier 1 contains 15 genes, including ELN, LTBP4, and ACAN that are highly expressed in aorta; Tier 2 contains 19 genes with more moderate expression; and Tier 3 contains 10 genes with lower (but still positive) expression in aorta and other tissues. Of note, 2 of 76 genes identified in our modifier screen were not assessed in the GTEX mRNA database. B, Two‐way clustering of 63 protein levels present in 32 normal human tissues also reveals varied levels of expression: Tier A contains 12 genes, including ACAN, FBLN1, HMCN1, and LTBP4 uniquely expressed in aorta, coronary, and tibial tissues; Tier B contains 22 genes including ELN highly expressed in aorta and other tissues; Tier C contains 17 genes with moderate expression in aorta and other tissues; Tier D contains 2 genes with lowest expression in aorta and artery coronary and artery tibial. Of note, 2 of 76 genes identified in our modifier screen were not assessed in the GTEX mRNA database. Similarly, 13 of the 76 genes were not queried in the protein database. EBV indicates Epstein‐Barr virus.