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. 2024 Apr 29;5:15. doi: 10.1186/s43556-024-00177-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Construction and secondary and tertiary structure analysis of the HP16118P. a Schematic diagram of HP16118P construction. The molecule contains 844 amino acids, with green representing HTL epitopes, blue representing CTL epitopes, and orange representing B cell epitopes. PSMα4 is a TLR-2 agonist, and PADRE and HBD-3 are auxiliary peptides. b Secondary structure of HP16118P. Pink highlights indicate α-helices, yellow regions represent β-sheets, and gray regions represent coils. c Visualization of the molecular docking between HP16118P and TLR-2 using PyMOL software. d Predicted two-dimensional representation of the interacting amino acid sites between HP16118P and TLR-2, with HP16118P represented in blue and TLR2 in green. The interacting amino acid sites between HP16118P and TLR2 may provide potential mechanisms for its immunomodulatory effects.