Fig. 2.

Prediction of innate and adaptive immune responses induced by HP16118P using the C-ImmSim server. The C-ImmSim server was used to predict the innate natural killer cells (a), macrophages (b), dendritic cells (c), epithelial cells (d), B cells (e), antibody levels (f), memory Th cells (g, classified by memory cell count), effector Th cells (h, classified by active, resting, non-responsive, and replicative counts), memory TC cells (i, classified by memory cell count), effector TC cells (j, classified by active, resting, non-responsive, and replicative counts), Th cell subtypes (k, including Th0, Th1, Th2, Th17), TR subgroups (l), and cytokine levels (m) induced by HP16118P after immune stimulation in humans. Abbreviations: TH Mem, memory T helper cells; TC, cytotoxic T cell; NK cells, natural killer cells; MA, macrophage; DC, dendritic cell; EP, epithelium; TR, regulatory T cells; Mem, Memory; TGF-β, transforming growth factor-β