Table 1.
List of information on the dominant epitopes of HTL, CTL and B cells constituting HP16118P
| Antigen | Peptide | Allele | Start | End | Length | Percentile rank a | Antigenicity scores b | IFN-γ scores c | Immunogenicity scored | Allergenicity |
|---|---|---|---|---|---|---|---|---|---|---|
| HTL peptide | ||||||||||
| Rv1736c | GAAFSWYTYSPTRVR | HLA-DQA1*02:01/DQB1*05:02 | 106 | 120 | 15 | 0.14 | 0.9205 | 0.4379 | NA | Non |
| VVLEFAATVDPEAGRRL | HLA-DQA1*05:01/DQB1*02:01 | 365 | 381 | 17 | 0.49 | 1.3268 | 0.3351 | NA | Non | |
| YESRLLRIASPMFHFGI | HLA-DRB1*14:04 | 456 | 472 | 17 | 0.2 | 0.8424 | 0.1577 | NA | Non | |
| Rv1737c | AVTLASILPVLAV | HLA-DQA1*06:01/DQB1*03:03 | 76 | 88 | 13 | 0.34 | 0.8199 | 0.3890 | NA | Non |
| MGSYALLVFFGLFL | HLA-DRB1*15:02 | 94 | 107 | 14 | 0.36 | 0.7974 | 0.1674 | NA | Non | |
| Rv1980c | SDPAYNINISLPSYYPDQ | HLA-DRB3*02:02 | 46 | 63 | 18 | 0.41 | 1.0470 | 2 | NA | Non |
| Rv1981c | FLFYSGFYLPMYWSS | HLA-DRB1*15:02 | 163 | 177 | 15 | 0.08 | 0.8181 | 1 | NA | Non |
| SFLFYSGFYLPMYWS | HLA-DRB1*15:02 | 162 | 176 | 15 | 0.08 | 0.8237 | 1 | NA | Non | |
| Rv2659c | DLRVHDLRHSGAVLAAST | HLA-DQA1*05:01/DQB1*03:01 | 312 | 329 | 18 | 0.44 | 0.9292 | 2 | NA | Non |
| Rv3429 | QSTARFILAYLPRWQ | HLA-DQA1*02:01/DQB1*05:02 | 153 | 167 | 15 | 0.28 | 0.7639 | 0.1360 | NA | Non |
| AAAEQLRLMYNSANMTAK | HLA-DRB3*02:02 | 25 | 42 | 18 | 0.41 | 0.7112 | 0.5479 | NA | Non | |
| Rv3873 | VAPSVMPAAAAGSSAT | HLA-DQA1*03:01/DQB1*06:01 | 304 | 319 | 16 | 0.31 | 1.0173 | 0.2373 | NA | Non |
| Rv3878 | GLSAAAAKLAGLVF | HLA-DQA1*03:01/DQB1*06:01 | 11 | 24 | 14 | 0.43 | 0.7126 | 0.6727 | NA | Non |
| TGAGARPAASPLAAPV | HLA-DQA1*05:01/DQB1*03:01 | 252 | 267 | 16 | 0.09 | 0.7544 | 0.6624 | NA | Non | |
| Rv3879 | TGREAAHLRAFRAYAA | HLA-DQA1*02:01/DQB1*05:02 | 670 | 685 | 16 | 0.01 | 0.7194 | 0.9824 | NA | Non |
| AAASGVPGARAAAAA | HLA-DQA1*05:01/DQB1*03:01 | 365 | 379 | 15 | 0.09 | 0.9853 | 0.7878 | NA | Non | |
| CTL peptide | ||||||||||
| Rv1736c | FHFGILVVI | HLA-C*06:02 | 468 | 476 | 9 | 0.32 | 1.0655 | NA | 0.2502 | Non |
| LFRPYIIYR | HLA-A*30:01 | 629 | 637 | 9 | 0.3 | 0.9571 | NA | 0.2374 | Non | |
| HAAGSRFVEL | HLA-C*03:04 | 210 | 219 | 10 | 0.23 | 0.9214 | NA | 0.1396 | Non | |
| Rv2031c | RPTFDTRLMR | HLA-A*11:01 | 32 | 41 | 10 | 0.21 | 1.3628 | NA | 0.1265 | Non |
| Rv2626c | NVMEEHQVRR | HLA-A*33:03 | 92 | 101 | 10 | 0.11 | 0.8767 | NA | 0.1287 | Non |
| Rv2656c | VAPTLAAAV | HLA-C*01:02 | 47 | 55 | 9 | 0.03 | 0.7845 | NA | 0.1173 | Non |
| Rv2659c | ASTARRVHK | HLA-A*30:01 | 168 | 176 | 9 | 0.06 | 0.8908 | NA | 0.2048 | Non |
| Rv1511 | LRPTEVDSL | HLA-C*07:02 | 281 | 289 | 9 | 0.13 | 1.2094 | NA | 0.0938 | Non |
| Rv3429 | MHPMIPAEY | HLA-C*07:02 | 1 | 9 | 9 | 0.04 | 0.8170 | NA | 0.0303 | Non |
| Rv3879c | RQRGRGDAL | HLA-B*15:01 | 479 | 487 | 9 | 0.23 | 1.0645 | NA | 0.1747 | Non |
| EAAHLRAFR | HLA-A*33:03 | 673 | 681 | 9 | 0.02 | 1.0320 | NA | 0.1845 | Non | |
| B-cell peptide | ||||||||||
| Rv1737c | LRDAPYFRPNADPVLPRLKAAA | 182 | 203 | 22 | NA | NA | NA | NA | Non | |
| Rv1978 | ANIREQAIATMPRGGPDASWLDRRFQTDALEYLDRDDVPDEVKQKIIGVLDRV | 4 | 56 | 53 | NA | NA | NA | NA | Non | |
| Rv2031c | LEDEMKEGRYEVRAELPGVDPDKDV | 42 | 66 | 25 | NA | NA | NA | NA | Non | |
| Rv2656c | TAVGGSPPTRRCPATEDRAPATVATPSSTDPTASRAVS | 2 | 39 | 38 | NA | NA | NA | NA | Non | |
| Rv2659c | AIEDHLHKHVNPGRESLLFPSVNDPNRHLA | 264 | 293 | 30 | NA | NA | NA | NA | Non | |
| Rv1511 | LIRRASTFNTSRIDHLYVDPHQPGARLFLHYGD | 31 | 63 | 33 | NA | NA | NA | NA | Non | |
| Rv3425 | GLANAYNDTRRKVVPPEEIAANREERRR | 90 | 117 | 28 | NA | NA | NA | NA | Non | |
| Rv3879c | TDQRLLDLLPPAPVDVNPPGDERHMLWFELMK | 632 | 663 | 32 | NA | NA | NA | NA | Non | |
aPercentile rank ranking of selected epitopes: select epitopes with a rank score of <0.5
bAntigenicity score: select epitopes with an antigenicity score of >0.7
cIFN-γ score: select epitopes with a positive score
dImmunogenicity score: select epitopes with an immunogenicity score >0
NA Not available