Table 3.
Thirty-five cytokines levels in three populations under two interventions with PBS and HP16118P
| Cytokines | Data presentation | ATB (n=14) | HC (n=14) | LTBI (n=16) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PBS (n=7) | HP16118P (n=7) | P value | PBS (n=7) | HP16118P (n=7) | P value | PBS (n=8) | HP16118P (n=8) | P value | ||
| G-CSF | Median (IQR) | 17.80 (13.50 to 27.10) | 331.45 (326.96 to 494.05) | <.001 | 17.09 ± 3.72 | 420.48 ± 172.73 | <.001 | 33.96 ± 49.60 | 322.90 ± 177.94 | 0.002 |
| GM-CSF | Median (IQR) | 0.00 (0.00 to 5.83) | 1460.48 (1078.05 to 2275.91) | 0.002 | 0.00 (0.00 to 0.00) | 1215.75 (911.34 to 1306.40) | 0.001 | 0.00 (0.00 to 28.43) | 1065.72 (701.82 to 1204.53) | 0.004 |
| HGF | Mean ± SD | 13.00 ± 3.71 | 12.01 ± 2.67 | 0.577 | 14.29 (13.63 to 14.84) | 14.84 (13.79 to 16.32) | 0.7 | 9.64 (8.43 to 10.25) | 10.75 (8.70 to 11.80) | 0.093 |
| IFN-α | Median (IQR) | 0.00 (0.00 to 0.00) | 0.11 (0.00 to 0.31) | 0.234 | 0.09 (0.01 to 0.33) | 0.24 (0.04 to 0.54) | 0.698 | 0.00 (0.00 to 0.26) | 0.00 (0.00 to 0.17) | 0.904 |
| IFN-γ | Median (IQR) | 0.87 (0.39 to 2.38) | 5.92 (2.90 to 29.51) | 0.012 | 7.42 (5.35 to 8.52) | 33.18 (16.19 to 60.74) | 0.055 | 4.39 (4.39 to 4.78) | 4.00 (3.20 to 18.59) | 0.559 |
| IL-1α | Mean ± SD | 5.50 ± 6.16 | 124.00 ± 31.84 | <.001 | 3.36 ± 1.05 | 172.72 ± 43.21 | <.001 | 3.13 (2.45 to 11.39) | 90.68 (69.50 to 124.84) | 0.002 |
| IL-1β | Median (IQR) | 12.41 (7.38 to 33.05) | 602.01 (437.81 to 1107.10) | <.001 | 14.71 (8.50 to 22.74) | 1579.41 (1165.08 to 1916.29) | <.001 | 12.71 (4.99 to 43.80) | 594.82 (391.36 to 629.30) | 0.002 |
| IL-10 | Median (IQR) | 2.90 (1.39 to 5.49) | 188.39 (109.16 to 289.03) | <.001 | 2.35 (1.54 to 2.45) | 186.71 (59.47 to 262.88) | 0.001 | 1.47 (1.06 to 4.37) | 103.94 (68.25 to 244.36) | 0.002 |
| IL-12p70 | Median (IQR) | 0.36 (0.34 to 0.38) | 0.96 (0.69 to 1.52) | <.001 | 0.45 (0.38 to 0.49) | 2.85 (1.22 to 16.02) | 0.002 | 0.41 (0.33 to 0.45) | 0.68 (0.42 to 3.29) | 0.126 |
| IL-13 | Mean ± SD | 2.20 ± 0.54 | 5.19 ± 3.42 | 0.061 | 2.72 ± 0.33 | 7.32 ± 3.54 | 0.014 | 2.39 ± 0.16 | 3.55 ± 1.03 | 0.015 |
| IL-17F | Mean ± SD | 2.13 ± 0.80 | 3.05 ± 0.78 | 0.048 | 2.94 ± 1.21 | 5.58 ± 2.53 | 0.028 | 2.05 ± 0.83 | 2.84 ± 0.72 | 0.062 |
| IL-2 | Mean ± SD | 4.27 ± 2.26 | 18.39 ± 7.80 | 0.002 | 5.70 ± 1.78 | 25.85 ± 4.85 | <.001 | 4.76 (4.42 to 5.42) | 11.48 (10.05 to 15.29) | 0.082 |
| IL-21 | Mean ± SD | 8.82 ± 5.63 | 18.48 ± 4.96 | 0.005 | 17.02 ± 5.34 | 24.66 ± 7.52 | 0.049 | 8.02 ± 8.03 | 18.05 ± 6.02 | 0.013 |
| IL-22 | Median (IQR) | 9.46 (9.33 to 10.18) | 13.35 (11.12 to 15.99) | 0.011 | 16.21 ± 3.41 | 35.13 ± 23.14 | 0.074 | 11.55 ± 4.08 | 13.27 ± 2.47 | 0.326 |
| IL-23 | Mean ± SD | 6.98 ± 3.78 | 332.38 ± 198.71 | 0.005 | 10.77 (10.39 to 11.88) | 370.42 (245.98 to 436.41) | 0.005 | 10.12 (8.32 to 11.10) | 228.48 (133.24 to 295.07) | 0.01 |
| IL-3 | Mean ± SD | 9.38 ± 1.31 | 10.35 ± 1.43 | 0.206 | 10.89 ± 1.12 | 11.92 ± 1.38 | 0.152 | 9.93 ± 1.50 | 10.77 ± 1.34 | 0.257 |
| IL-31 | Mean ± SD | 1.91 ± 0.97 | 3.84 ± 1.02 | 0.003 | 3.55 ± 1.41 | 4.99 ± 1.30 | 0.071 | 3.29 ± 1.50 | 4.13 ± 1.31 | 0.253 |
| IL-4 | Mean ± SD | 2.94 ± 1.28 | 11.45 ± 5.33 | 0.005 | 6.72 (5.81 to 7.06) | 14.79 (14.15 to 17.64) | 0.004 | 4.47 ± 2.22 | 8.11 ± 4.41 | 0.056 |
| IL-5 | Mean ± SD | 3.62 ± 2.93 | 38.60 ± 14.85 | <.001 | 2.35 ± 1.37 | 49.42 ± 13.05 | <.001 | 1.70 (0.00 to 3.25) | 24.80 (17.75 to 26.36) | 0.004 |
| IL-6 | Mean ± SD | 3521.82 ± 2806.94 | 8106.69 ± 2618.21 | 0.008 | 1870.48 ± 1663.45 | 15640.37 ± 8202.15 | 0.004 | 2832.08 ± 3729.50 | 9198.03 ± 6471.14 | 0.03 |
| IL-8 | Mean ± SD | 4047.66 ± 1415.14 | 4207.92 ± 1428.47 | 0.837 | 6437.56 ± 886.20 | 5181.07 ± 2818.90 | 0.297 | 6169.91 (5366.49 to 6578.14) | 6241.64 (3480.94 to 6726.94) | 0.798 |
| IL-9 | Mean ± SD | 32.84 ± 7.44 | 31.19 ± 6.40 | 0.665 | 38.61 (35.85 to 40.58) | 36.79 (31.13 to 38.27) | 0.337 | 31.21 ± 7.75 | 28.81 ± 5.64 | 0.49 |
| IP-10 | Median (IQR) | 3.08 (2.75 to 3.39) | 3.99 (3.52 to 4.63) | 0.053 | 5.85 ± 2.84 | 27.15 ± 22.16 | 0.044 | 3.02 (2.57 to 4.15) | 3.16 (2.60 to 8.77) | 0.721 |
| MCP-1 | Median (IQR) | 895.93 (736.03 to 2934.16) | 1212.04 (389.52 to 2133.46) | 0.535 | 4704.88 ± 3117.15 | 1633.29 ± 2025.52 | 0.049 | 1317.71 (427.45 to 3620.39) | 1261.64 (508.38 to 1975.10) | 0.721 |
| MCP-3 | Mean ± SD | 106.77 ± 55.58 | 52.29 ± 11.90 | 0.041 | 109.06 ± 79.77 | 48.00 ± 31.24 | 0.097 | 71.36 ± 44.13 | 36.20 ± 18.80 | 0.067 |
| MIG | Median (IQR) | 1.26 (0.98 to 1.49) | 1.56 (1.21 to 1.95) | 0.318 | 4.50 ± 3.33 | 16.52 ± 14.29 | 0.069 | 1.20 (0.92 to 1.40) | 1.22 (0.92 to 2.62) | 0.721 |
| MIP-1α | Mean ± SD | 83.92 ± 25.68 | 71.24 ± 22.66 | 0.347 | 157.35 ± 55.52 | 84.32 ± 44.02 | 0.018 | 89.88 ± 41.51 | 91.59 ± 48.27 | 0.94 |
| MIP-1β | Mean ± SD | 1449.22 ± 700.81 | 4799.87 ± 1483.02 | <.001 | 2150.89 (1941.74 to 2924.59) | 7945.38 (4251.00 to 10742.42) | 0.053 | 1265.81 ± 886.36 | 4912.32 ± 3114.64 | 0.013 |
| PD-1 | Mean ± SD | 2.85 ± 1.47 | 12.05 ± 6.53 | 0.009 | 5.37 ± 2.35 | 14.85 ± 6.10 | 0.005 | 2.63 ± 1.62 | 8.52 ± 4.61 | 0.008 |
| SDF-1α | Median (IQR) | 23.71 (8.41 to 59.72) | 51.34 (32.51 to 59.82) | 0.607 | 25.01 ± 15.54 | 47.05 ± 40.70 | 0.219 | 83.54 ± 44.75 | 102.78 ± 54.31 | 0.452 |
| TIM-3 | Mean ± SD | 282.51 ± 64.62 | 256.02 ± 43.57 | 0.386 | 350.65 ± 69.92 | 358.47 ± 98.13 | 0.866 | 242.40 ± 85.93 | 286.76 ± 41.90 | 0.21 |
| TIMP-1 | Mean ± SD | 54972.72 ± 21062.35 | 34651.69 ± 13061.73 | 0.051 | 89259.60 (65187.51 to 136669.11) | 56257.84 (39887.43 to 69856.31) | 0.073 | 71822.68 (43546.99 to 76033.65) | 39979.36 (27456.73 to 48734.38) | 0.161 |
| TNF-α | Median (IQR) | 57.93 (23.71 to 72.26) | 1299.13 (947.03 to 1893.37) | <.001 | 31.92 ± 10.71 | 2483.02 ± 1463.95 | 0.004 | 47.01 ± 70.63 | 590.75 ± 305.89 | 0.001 |
| VEGF-A | Mean ± SD | 841.61 ± 364.54 | 131.33 ± 38.63 | 0.002 | 1172.88 ± 405.70 | 167.79 ± 75.58 | <.001 | 1179.86 ± 392.71 | 306.30 ± 365.52 | <.001 |
| VEGF-R2 | Mean ± SD | 36.79 ± 36.54 | 13.12 ± 27.76 | 0.197 | 80.46 (51.38 to 89.36) | 92.43 (67.35 to 101.15) | 0.521 | 49.51 ± 39.77 | 29.38 ± 23.09 | 0.236 |
Bold indicates P value <0.05