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. 2024 Mar 20;70:102501. doi: 10.1016/j.eclinm.2024.102501

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© 2024 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Treatment effects (log hazard ratio [HR]) on overall survival (OS) vs treatment effects on intermediate clinical endpoints. (A) Log (HR)OS vs log (HR)DFS; (B) log (HR)OS vs log (HR)DDFS; (C) log (HR)OS vs log (HR)RFS; (D) log (HR)OS vs log (HR)DRFS; (E) log (HR)OS vs log (HR)IBCFS; (F) log (HR)OS vs log (HR)RFI; (G) log (HR)OS vs log (HR)DRFI; (H) log (HR)OS vs log (HR)BCFI. OS, overall survival; DFS, disease-free survival; DDFS, distant disease-free survival; RFS, recurrence-free survival; DRFS, distant relapse-free survival; IBCFS, invasive breast cancer–free survival; RFI, recurrence-free interval; DRFI, distant recurrence-free interval; BCFI, breast cancer-free interval.

Fig. 3 — Treatment effects (log hazard ratio [HR]) on overall survival (OS) vs treatment effects on intermediate clinical endpoints. (A) Log (HR)OS vs log (HR)DFS; (B) log (HR)OS vs log (HR)DDFS; (C) log (HR)OS vs log (HR)RFS; (D) log (HR)OS vs log (HR)DRFS; (E) log (HR)OS vs log (HR)IBCFS; (F) log (HR)OS vs log (HR)RFI; (G) log (HR)OS vs log (HR)DRFI; (H) log (HR)OS vs log (HR)BCFI. OS, overall survival; DFS, disease-free survival; DDFS, distant disease-free survival; RFS, recurrence-free survival; DRFS, distant relapse-free survival; IBCFS, invasive breast cancer–free survival; RFI, recurrence-free interval; DRFI, distant recurrence-free interval; BCFI, breast cancer-free interval.