Table E4.
Characteristics of included randomized controlled trials stratified by continents
| Characteristic | Asia |
Europe |
North America |
South America |
Africa |
Oceania |
|---|---|---|---|---|---|---|
| N = 34∗ | N = 22∗ | N = 14∗ | N = 13∗ | N = 2∗ | N = 1∗ | |
| Overall status group | ||||||
| Completed | 5 (14.7%) | 13 (59.1%) | 4 (28.6%) | 4 (30.8%) | 2 (100.0%) | |
| Recruiting | 14 (41.2%) | 2 (9.1%) | 4 (28.6%) | 3 (23.1%) | ||
| Active, not recruiting | 1 (2.9%) | 3 (21.4%) | 3 (23.1%) | 1 (100.0%) | ||
| Not yet recruiting | 1 (2.9%) | 1 (7.1%) | ||||
| Stopped | 1 (2.9%) | 3 (13.6%) | 2 (14.3%) | 2 (15.4%) | ||
| Unknown | 12 (35.3%) | 4 (18.2%) | 1 (7.7%) | |||
| Periods | ||||||
| Year 2000 and earlier | 1 (2.9%) | 6 (27.3%) | 3 (21.4%) | 3 (23.1%) | 2 (100.0%) | |
| Year 2001-2010 | 1 (2.9%) | 4 (18.2%) | 4 (28.6%) | 5 (38.5%) | 1 (100.0%) | |
| Year 2011-2015 | 7 (20.6%) | 5 (22.7%) | ||||
| Year 2016-2020 | 19 (55.9%) | 5 (22.7%) | 4 (28.6%) | 3 (23.1%) | ||
| Year 2021-2023 | 6 (17.6%) | 2 (9.1%) | 3 (21.4%) | 2 (15.4%) | ||
| Masking | ||||||
| Open label | 24 (70.6%) | 11 (50.0%) | 12 (85.7%) | 12 (92.3%) | 2 (100.0%) | 1 (100.0%) |
| Single blinded | 3 (8.8%) | 3 (13.6%) | 2 (14.3%) | 1 (7.7%) | ||
| Double blinded | 3 (8.8%) | 4 (18.2%) | ||||
| Triple blinded | 3 (8.8%) | 2 (9.1%) | ||||
| Quadruple blinded | 1 (2.9%) | |||||
| NULL | 2 (9.1%) | |||||
| Single facility | ||||||
| True | 25 (73.5%) | 13 (59.1%) | 5 (35.7%) | 3 (23.1%) | ||
| Lead sponsor category | ||||||
| Federal | 3 (21.4%) | 3 (23.1%) | ||||
| Industry | 3 (8.8%) | 2 (9.1%) | 2 (14.3%) | 2 (15.4%) | 1 (50.0%) | |
| Institutional | 31 (91.2%) | 17 (77.3%) | 3 (21.4%) | 2 (15.4%) | ||
| Network | 3 (13.6%) | 6 (42.9%) | 6 (46.2%) | 1 (50.0%) | 1 (100.0%) | |
| Comparison types | ||||||
| Different intraoperative technical management | 10 (29.4%) | 3 (13.6%) | 3 (21.4%) | 2 (15.4%) | ||
| Different modalities of lobectomy | 4 (11.8%) | 4 (18.2%) | 1 (7.1%) | |||
| Different patient management strategies | 8 (23.5%) | 7 (31.8%) | 1 (7.1%) | 2 (15.4%) | ||
| Different types of lung resection | 7 (20.6%) | 1 (7.1%) | 1 (7.7%) | 1 (100.0%) | ||
| Surgery + adjunct treatments | 3 (8.8%) | 4 (18.2%) | 4 (28.6%) | 4 (30.8%) | 1 (50.0%) | |
| Surgery vs nonsurgical treatments | 2 (5.9%) | 4 (18.2%) | 4 (28.6%) | 4 (30.8%) | 1 (50.0%) | |
| No. of arms | ||||||
| 2 | 33 (97.1%) | 21 (95.5%) | 14 (100.0%) | 13 (100.0%) | 2 (100.0%) | 1 (100.0%) |
| 3 | 1 (2.9%) | 1 (4.5%) | ||||
| Actual enrollment | ||||||
| Mean (SD) | 166 (106) | 196 (168) | 317 (248) | 317 (248) | 346 (117) | 701 (NA) |
| Median (IQR) | 180 (82-232) | 230 (43-297) | 354 (118-454) | 354 (118-454) | 346 (304-388) | 701 (701-701) |
| Unknown | 27 | 11 | 7 | 6 | ||
| Estimated/target enrollment | ||||||
| Mean (SD) | 375 (345) | 373 (302) | 510 (406) | 508 (419) | 605 (134) | 1297 (NA) |
| Median (IQR) | 252 (114-490) | 300 (94-600) | 574 (100-670) | 542 (100-728) | 605 (558-652) | 1297 (1297-1297) |
| Unknown | 1 | 1 | 1 |
SD, Standard deviation; IQR, interquartile range; NA, not available.
∗
n (%) for categorical variables; mean (SD) and median (IQR) for continuous variables.