Figure 1.

A, Cell lines were characterized by expression levels of E-cadherin and vimentin. H441 and H358 expressed an epithelial phenotype–high E-cadherin and low vimentin. Lines H1299 and SW1573 expressed a mesenchymal phenotype–low E-cadherin and high vimentin. B, The lung cancer cell lines were separated into 4 subtypes: epithelial (E) (H441), intermediate epithelial (iE) (H358), intermediate mesenchymal (iM) (H1299), and mesenchymal (M) (SW1573). TC-1 was selected as a syngeneic cell line to balance differences of lung cancer cell phenotypes. Cell lines were exposed to losartan and significant decreases in vimentin (C) and E-cadherin (D) were observed (P < .05).