Figure 2.

A, E-cadherin incrementally increased with cisplatin treatment, demonstrated dose-dependent increase with losartan, and significantly increased with combination losartan and cisplatin treatment over phosphate buffered saline (PBS) or single-drug treatment (P < .05). B, Vimentin decreased with cisplatin and showed a dose-dependent decrease with losartan. Combination losartan and cisplatin significantly reduced vimentin expression over PBS or single-drug treatment (P < .05). C, Cell viability was reduced with cisplatin and losartan individually, and combination treatment significantly reduced cell viability below single-drug treatment (P < .05). D through F, Epithelial-mesenchymal transition (EMT) mediators Twist 1, Snail 1, and Zeb 1 were significantly reduced with cisplatin and losartan monotreatment and demonstrated significant reduction with combination treatment below the single-agent treatment result (P < .05).