Table 2.
Variables | RIPC (n = 60) | Control (n = 60) |
---|---|---|
Anesthesia | ||
Volatile anesthetic agent: isoflurane | 56 (93%) | 55 (92%) |
Volatile anesthetic agent: sevoflurane | 4 (7%) | 5 (8%) |
MAC volatile anesthetic pre-CPB, % | 0.7 [0.6-0.9] | 0.8 [0.7-1.0] |
Time from start of intervention to aortic XC, min | 93 [81-105] | 92 [77-103] |
In TOF repair | (n = 34) | (n = 34) |
RVOT muscle resected | 34 (100%) | 33 (97%) |
RVOT stent removed∗ | 6 (86%) | 7 (100%) |
RVOT/TA/PA patch used | 32 (94%) | 33 (97%) |
RV-PA conduit used | 2 (6%) | 1 (3%) |
In isolated VSD closure | (n = 26) | (n = 26) |
RVOT muscle resected | 5 (19%) | 3 (12%) |
VSD closed | 60 (100%) | 59 (98%)† |
Total CPB time, min | 91.0 [67.0-114.0] | 87.5 [70.0-106.5] |
Repeat CPB required | 7 (12%) | 5 (8%) |
Total aortic XC time, min | 64.0 [45.0-84.5] | 58.5 [44.5-74.0] |
Repeat aortic XC required | 6 (10%) | 5 (8%) |
Type of cardioplegia used | ||
Cold blood | 54 (90%) | 53 (88%) |
Cold crystalloid | 6 (10%) | 6 (10%) |
Warm blood | 0 | 1 (2%) |
No. of cardioplegia doses | 2 [2-3] | 2 [2-3] |
Total cardioplegia volume, mL | 360 [272-450] | 369 [294-450] |
Postoperative recovery | ||
Drain loss at 12 h, mL | 55.0 [45.0-87.5] | 79.5 [40.0-107.5] |
Blood transfusion post-CPB in first 12 h | 13 (22%) | 11 (18%) |
Volume blood transfused in first 12 h, mL/kg in those transfused | 75 [55-100] | 50 [30-80] |
Hemoglobin at 12 h, g/dL | 119 [111-134] | 119 [107-130] |
Time to extubation, h | 6.3 [3.7-15.2] | 6.9 [3.6-13.3] |
Data are median [IQR] when appropriate. RIPC, Remote ischemic preconditioning; MAC, minimum alveolar concentration; CPB, cardiopulmonary bypass; XC, crossclamp; TOF, tetralogy of Fallot; RVOT, right ventricular outflow tract; TA, transannular; PA, pulmonary artery; RV-PA, right ventricle to pulmonary artery; VSD, ventricular septal defect.
Of the 7 participants in each treatment arm with TOF and an RVOT stent.
Small infant with TOF and bilateral superior vena cavae in whom an RV-PA conduit was placed but complete repair was abandoned.