Table 2.

Mendelian randomization results of causal effects of male infertility on risk of stroke and its subtypes.

Method	SNPs, n	OR	95% CI	p value
All stroke
IVW	24	0.96	0.90-1.02	0.188
MR Egger	24	0.96	0.84-1.10	0.579
Weighted median	24	0.97	0.89-1.06	0.472
Simple mode	24	0.99	0.85-1.14	0.855
Weighted mode	24	0.96	0.84-1.10	0.567
Any ischemic stroke
IVW	24	0.97	0.91-1.04	0.414
MR Egger	24	0.94	0.82-1.09	0.455
Weighted median	24	0.96	0.88-1.06	0.415
Simple mode	24	1.02	0.87-1.20	0.768
Weighted mode	24	0.97	0.85-1.12	0.708
Large artery stroke
IVW	24	0.94	0.79-1.12	0.518
MR Egger	24	0.80	0.55-1.18	0.278
Weighted median	24	0.97	0.75-1.24	0.784
Simple mode	24	0.94	0.58-1.52	0.810
Weighted mode	24	1.01	0.66-1.55	0.964
Cardioembolic stroke
IVW	23	0.95	0.82-1.09	0.424
MR Egger	23	0.68	0.50-0.91	0.018
Weighted median	23	0.94	0.77-1.15	0.564
Simple mode	23	1.00	0.69-1.45	0.996
Weighted mode	23	0.97	0.68-1.38	0.862
Small vessel stroke
IVW	24	0.82	0.68-0.99	0.044
MR Egger	24	0.89	0.59-1.35	0.589
Weighted median	24	0.89	0.71-1.12	0.323
Simple mode	24	1.02	0.67-1.54	0.935
Weighted mode	24	0.96	0.68-1.35	0.798

CI, confidence interval; IVW, inverse-variance-weighted; MR, Mendelian randomization; OR, odds ratio; SNP, single nucleotide polymorphism.