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. 2024 Mar 27;71:102563. doi: 10.1016/j.eclinm.2024.102563

Table 3.

Secondary outcomes between baseline and 12 months.

Baseline 3 months 6 months 12 months p value
Radiopaque pellets test (number of radiopaque pellets on day 7)
 Donor FMT 20.6 (2.0) 22.1 (2.1) 19.2 (2.1) 19.4 (2.1) 0.0252
 Placebo FMT 18.6 (2.1) 19.4 (2.1) 23.7 (2.1) 25.5 (2.2)
Levodopa-equivalent daily dose (mg)
 Donor FMT 383.0 (53.3) 398.8 (57.2) 399.5 (57.0) 429.1 (59.0) 0.8350
 Placebo FMT 431.1 (50.8) 429.7 (54.7) 442.1 (54.5) 455.9 (56.5)
Non-Motor Symptoms Scale for Parkinson's Disease (NMSS)
 Donor FMT 45.8 (9.1) 50.1 (8.9) 48.2 (8.6) 54.7 (8.3) 0.1443
 Placebo FMT 44.4 (8.6) 31.6 (8.5) 35.9 (8.3) 33.4 (8.0)
Parkinson's Disease Quality of Life Questionnaire (PDQ-39)
 Donor FMT 34.4 (4.7) 32.8 (4.5) 35.4 (4.8) 36.5 (4.6) 0.5439
 Placebo FMT 26.2 (4.4) 24.3 (4.3) 26.8 (4.6) 25.0 (4.5)
Wexner Constipation Scale
 Donor FMT 6.7 (1.3) 6.8 (1.0) 6.7 (1.0) 6.7 (1.1) 0.7696
 Placebo FMT 5.8 (1.2) 5.5 (1.0) 4.7 (1.0) 5.1 (1.0)
Geriatric Depression Scale (GDS)
 Donor FMT 17.5 (0.7) 17.2 (0.6) 17.4 (0.6) 16.8 (0.6) 0.1674
 Placebo FMT 17.3 (0.6) 17.3 (0.6) 17.7 (0.5) 18.3 (0.6)
Parkinson Anxiety Scale (PAS)
 Donor FMT 8.7 (1.8) 9.7 (1.7) 8.1 (1.7) 9.6 (1.7) 0.1519
 Placebo FMT 8.8 (1.7) 8.0 (1.6) 8.2 (1.6) 8.2 (1.6)
Lille Apathy Rating Scale (LARS)
 Donor FMT −19.4 (1.5) −19.8 (1.6) −19.0 (1.5) −19.3 (1.4) 0.4253
 Placebo FMT −20.7 (1.4) −21.2 (1.5) −21.9 (1.5) −22.4 (1.3)
Parkinson's Disease Sleep Scale (PDSS)
 Donor FMT 101.1 (5.7) 104.5 (5.5) 101.3 (5.4) 102.7 (5.3) 0.7290
 Placebo FMT 109.7 (5.4) 109.7 (5.3) 108.8 (5.3) 110.5 (5.1)
Parkinson's Fatigue Scale (PFS)
 Donor FMT 37.3 (3.2) 39.6 (2.9) 40.0 (3.1) 43.4 (3.2) 0.0418
 Placebo FMT 34.7 (3.0) 35.7 (2.8) 34.7 (3.0) 33.4 (3.2)
Montreal Cognitive Assessment (MoCA)
 Donor FMT 27.6 (0.3) 28.4 (0.3) 28.2 (0.2) 0.4828
 Placebo FMT 28.2 (0.3) 28.7 (0.3) 28.9 (0.2)

Data are mean (SEM). MDS-UPDRS, Movement Disorders Society Unified Parkinson's Disease Rating Scale. Significant differences (p < 0.05) are indicated in bold.