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. 2024 Apr 8;102:skae103. doi: 10.1093/jas/skae103

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© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society of Animal Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — The putative structure of the PLAG1 gene in cattle and variants of PLAG1 associated with different phenotypes. Indel, insertion/deletion; SNPs, single-nucleotide polymorphisms (top); the common bi-directional promoter of the PLAG1 and CHCHD7 genes. QTLs/SNPs in the promoter influence the transcriptional activity of PLAG1 and CHCHD7 and phenotypes in cattle including growth and stature. QTLs, quantitative trait loci; SNPs, single-nucleotide polymorphisms (middle); and the structure of PLAG1 protein and domains associated with translocation to the nucleus and binding to DNA. PLAG1 typically binds to the promoter of target genes to influence transcription (bottom).