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Insulin-like growth factor 2 (IGF2) is produced by oocytes and granulosa cells of follicles and has a local and reciprocal action in oocytes and follicles. IGF2 is an important mitogen and can bind to both IGF1 and IGF2 receptors at target cells. The IGF2 gene is influenced by PLAG1 protein which provides a mechanism for PLAG1 to be associated with oocyte and follicular function.
