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Insulin-like growth factor 2 (IGF2) is produced by the embryo and uterine stroma and has a local and reciprocal action in embryos and uterus. IGF2 is an important mitogen and can bind to both IGF1 and IGF2 receptors at target cells. The IGF2 gene is influenced by PLAG1 protein which provides a mechanism for PLAG1 to be associated with embryonic and uterine function.
