Table 1.
Discovery of the pleomorphic adenoma gene (PLAG1) family members
| Name | Function described | Year | Species | Reference |
|---|---|---|---|---|
| PLAG1: pleomorphic adenoma gene | Activation in salivary gland tumorigenesis | 1997 | Human | Kas et al. 1997a, b |
| * LOT1: lost-on-transformation | Decreased or lost expression in transformed ovarian epithelia cells that developed into malignant ovarian tumors | 1997 | Rat | Abdollahi et al. 1997a, b; see also Abdollahi 2007 |
| * ZAC/ ZAC1: zinc-finger protein found to regulate apoptosis and cell cycle arrest | Induction of apoptosis and G1 cell cycle arrest and inhibition of tumor growth | 1997 | Mouse | Spengler et al. 1997 |
|
*
PLAGL1: PLAG1 like zinc-finger 1 PLAGL2: PLAG1 like zinc-finger protein 2 |
Identified by screening mouse embryo and human fetal kidney cDNA libraries using PLAG1 open reading frames (ORF) | 1998 | Human, Mouse | Kas et al. 1998 |
*Same PLAG/PLAG family member.