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. 2024 Apr 10;67(8):6610–6623. doi: 10.1021/acs.jmedchem.4c00037

Table 3. EC50 of LPS Biosynthesis Inhibition of Clinical Isolates by Compound 17 in the Presence of 100 μM Glucose-6-Phosphate (n = 1).

strain resistance mechanism EC50 of LPS heptosylation by 17 (μM)
E. coli S1 ESBL 21
E. cloacae S2 AmpC 18
K. pneumoniae S3 NDM-1 21