TABLE 1.
Primary diagnosis | |||||
---|---|---|---|---|---|
Endometriosis | Male factor | ||||
Characteristic | n | % | n | % | P value |
Total | 112,475 | 375,557 | |||
Age (y) | < .0001 | ||||
<35 | 56,156 | 49.9 | 180,322 | 48.0 | |
35–37 | 27,330 | 24.3 | 83,319 | 22.2 | |
38–40 | 20,037 | 17.8 | 70,508 | 18.8 | |
41–42 | 6,441 | 5.7 | 27,600 | 7.4 | |
43–44 | 2,092 | 1.9 | 10,878 | 2.9 | |
≥45 | 419 | 0.4 | 2,930 | 0.8 | |
Race/ethnicitya | < .0001 | ||||
Non-Hispanic white | 54,288 | 80.4 | 171,507 | 76.0 | |
Non-Hispanic black | 2,642 | 3.9 | 13,657 | 6.1 | |
Asian/Pacific islander | 6,142 | 9.1 | 22,199 | 9.8 | |
Hispanic | 4,414 | 6.5 | 17,880 | 7.9 | |
Other | 84 | 0.1 | 391 | 0.2 | |
Concomitant diagnosis | |||||
Ovulatory dysfunction | 9,951 | 8.9 | 47,387 | 12.6 | < .0001 |
Tubal factor | 21,198 | 18.9 | 37,391 | 10.0 | < .0001 |
Diminished ovarian reserve | 14,863 | 13.2 | 61,618 | 16.4 | < .0001 |
No. of prior ART cycles | .0077 | ||||
0 | 62,221 | 55.4 | 209,571 | 55.8 | |
1 | 23,356 | 20.8 | 76,625 | 20.4 | |
2+ | 26,820 | 23.9 | 89,091 | 23.7 | |
No. of prior pregnancies | < .0001 | ||||
0 | 59,921 | 53.3 | 198,509 | 52.9 | |
1 | 30,747 | 27.4 | 98,867 | 26.4 | |
2+ | 21,701 | 19.3 | 77,575 | 20.7 | |
No. of prior spontaneous abortions | < .0001 | ||||
0 | 80,761 | 72.0 | 281,045 | 75.2 | |
1 | 21,866 | 19.5 | 65,906 | 17.6 | |
2+ | 9,573 | 8.5 | 27,000 | 7.2 | |
No. of prior preterm births | < .0001 | ||||
0 | 110,110 | 98.2 | 366,005 | 98.0 | |
1 | 1,873 | 1.7 | 6,608 | 1.8 | |
2+ | 159 | 0.1 | 737 | 0.2 | |
No. of prior full-term births | < .0001 | ||||
0 | 88,712 | 79.0 | 284,526 | 76.0 | |
1 | 20,678 | 18.4 | 71,211 | 19.0 | |
2+ | 2,862 | 2.6 | 18,594 | 5.0 | |
Mean maximum serum FSH (SD)a | 7.98 | 4.9 | 7.54 | 4.4 | < .0001 |
Cycle history | < .0001 | ||||
First IVF, no previous live birth | 52,453 | 46.8 | 171,171 | 45.7 | |
First IVF, ≥1 previous live birth | 9,653 | 8.6 | 37,668 | 10.1 | |
≥1 previous IVF, no previous live birth | 34,627 | 30.9 | 107,960 | 28.9 | |
≥1 previous IVF, ≥1 previous live birth | 15,462 | 13.8 | 57,413 | 15.3 | |
Stimulation protocol (only 2004+ data)a | < .0001 | ||||
Agonist standard | 34,515 | 48.7 | 132,966 | 49.7 | |
Agonist flare | 9,057 | 12.8 | 29,472 | 11.0 | |
Antagonist | 21,788 | 30.7 | 84,912 | 31.7 | |
Clomid ± FSH | 1,015 | 1.4 | 3,336 | 1.3 | |
FSH only | 2,160 | 3.0 | 7,856 | 2.9 | |
Unstimulated | 611 | 0.9 | 2,759 | 1.0 | |
Other | 1,797 | 2.5 | 6,489 | 2.4 | |
Mean total FSH dose (SD)a | 3,274.32 | 1,732.2 | 3,106.54 | 1,672.1 | < .0001 |
Ovarian hyperstimulation | < .0001 | ||||
Yes | 1,187 | 1.1 | 4,929 | 1.3 | |
No | 111,287 | 98.9 | 370,625 | 98.7 | |
Cycle cancellation total | < .0001 | ||||
Before retrieval | 14,474 | 12.9 | 37,936 | 10.1 | |
Between retrieval and transfer | 6,281 | 5.6 | 23,084 | 6.2 | |
Not cancelled | 91,720 | 81.6 | 314,537 | 83.8 | |
Hospitalization | 337 | 0.3 | 1,175 | 0.3 | .4832 |
All missing <1% except race/ethnicity (39.9%), maximum serum FSH (25.5%), and mean FSH dose (3.7%).