TABLE 2.
Risks of first trimester pregnancy loss by infertility diagnosis in fresh autologous IVF cycles, stratified by maternal age.
| Age (y), <30 | Age (y), 30–34 | Age (y), 35–37 | Age (y), 38–40 | Age (y), >40 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable | % of lossesa | aRR (95% CI) | % of lossesa | aRR (95% CI) | % of lossesa | aRR (95% CI) | % of lossesa | aRR (95% CI) | % of lossesa | aRR (95% CI) |
| Male factor | ||||||||||
| Yes | 8.3 | 1.05 (0.99–1.11) | 9.8 | 0.99 (0.95–1.03) | 13.7 | 1.01 (0.97–1.05) | 21.5 | 1.03 (0.99–1.07) | 37.1 | 0.97 (0.93–1.02) |
| No | 8.2 | 1 | 10.2 | 1 | 13.7 | 1 | 21.6 | 1 | 37.1 | 1 |
| Ovulatory dysfunction | ||||||||||
| Yes | 8.9 | 1.12 (1.05–1.19) | 10.6 | 1.07 (1.02–1.13) | 13.9 | 1.02 (0.96–1.07) | 20.8 | 1.02 (0.96–1.08) | 37.0 | 1.02 (0.94–1.11) |
| No | 8.0 | 1 | 9.9 | 1 | 13.6 | 1 | 21.6 | 1 | 37.1 | 1 |
| Diminished ovarian reserve | ||||||||||
| Yes | 8.8 | 1.00 (0.87–1.15) | 11.5 | 1.08 (1.01–1.15) | 14.7 | 1.02 (0.97–1.07) | 23.3 | 1.02 (0.99–1.06) | 38.4 | 1.04 (0.99–1.10) |
| No | 8.2 | 1 | 9.9 | 1 | 13.5 | 1 | 20.8 | 1 | 35.9 | 1 |
| Endometriosis | ||||||||||
| Yes | 7.8 | 1.00 (0.91–1.01) | 10.1 | 1.00 (0.94–1.05) | 13.9 | 1.01 (0.95–1.07) | 21.8 | 1.08 (1.01–1.14) | 39.8 | 1.09 (0.98–1.20) |
| No | 8.3 | 1 | 10.0 | 1 | 13.6 | 1 | 21.5 | 1 | 37.0 | 1 |
| Tubal factor | ||||||||||
| Yes | 8.4 | 1.08 (0.98–1.18) | 10.2 | 1.02 (0.97–1.07) | 13.6 | 0.98 (0.93–1.03) | 22.0 | 1.03 (0.98–1.08) | 37.5 | 1.01 (0.95–1.08) |
| No | 8.2 | 1 | 10.0 | 1 | 13.7 | 1 | 21.4 | 1 | 37.1 | 1 |
| Uterine factor | ||||||||||
| Yes | 11.1 | 1.24 (1.04–1.48) | 13.6 | 1.27 (1.17–1.38) | 16.7 | 1.12 (1.03–1.21) | 25.5 | 1.08 (1.01–1.17) | 40.9 | 1.04 (0.95–1.13) |
| No | 8.2 | 1 | 9.9 | 1 | 13.5 | 1 | 21.3 | 1 | 36.9 | 1 |
Note: Models were adjusted for number of prior miscarriages, number of prior births, number of prior ART cycles, the use of assisted hatching, the number of supernumerary embryos cryopreserved, and the number of fetal heartbeats on first ultrasound. aRR = adjusted risk ratio; = assisted reproductive technology; CI = confidence interval.
a
% of first trimester losses in clinical pregnancies.