Table 1.

Current Indications for HSCT in Patients With SCD (One or More of the Following Complications) ¹⁵ .

Donor	Indications for HSCT
MSD	Stroke or central nervous system event lasting >24 h Impaired cognition/neuropsychological function with abnormal cerebral MRI/MRA Elevated TCD velocity Recurrent acute chest syndrome Recurrent pain/ Veno-occlusive episodes (VOE) Red cell alloimmunization Pulmonary hypertension/ Tricuspid regurgitation jet velocity (TRJV)> 2.5 m/s Osteonecrosis/ Avascular necrosis (AVN) Recurrent priapism Sickle nephropathy Sickle retinopathy Sickle lung disease
MUD	Stroke or central nervous system event lasting >24 h Elevated TCD velocity unresponsive to HU or chronic blood transfusion therapy Recurrent acute chest syndrome despite supportive care Recurrent pain/VOE despite supportive care Red cell alloimmunization despite intervention plus established indication for chronic transfusion therapy Pulmonary hypertension/ Tricuspid regurgitation jet velocity> 2.5 m/s Recurrent priapism Sickle nephropathy Osteonecrosis /(AVN)
Alternative donor	Recurrent stroke despite adequate chronic transfusion therapy or progressive central nervous system changes Inability to tolerate supportive care though strongly indicated, eg, red cell alloimmunization, severe VOE and inability to tolerate HU

HU: hydroxyurea; MRI/MRA: magnetic resonance imaging/ magnetic resonance angiography; MSD: matched sibling donor; MUD: matched unrelated donor; TCD: transcranial Doppler.