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. 2024 Apr 23;31(2):130–141. doi: 10.21315/mjms2024.31.2.11

Table 2.

The highest and lowest value of BMDL10 (mg/kg bw/day) of different types of PAHs and HCAs on different genders at different durations of exposure

Chemical Fluoranthene Benzo[a]pyrene MeIQx PhIP
Gender Ma Fa Ma Fa Mb Fb Mc Md Fd

Duration 6 months 9 months 104 weeks 56 weeks 104 weeks
Lung adenoma Highest BMDL10 0.17 0.22 0.05 - - - - - -
Lowest BMDL10 0.08 0.09 0.01 - - - - - -

Lung adenocarcinoma Highest BMDL10 0.30 0.52 0.19 0.29 - - - - -
Lowest BMDL10 0.16 0.52 0.12 0.25 - - - - -

Stomach cancer Highest BMDL10 - - - - - 2.68 - - -
Lowest BMDL10 - - - - - 1.69 - - -

Liver cancer Highest BMDL10 - - - - 2.42 2.90 1.33 - -
Lowest BMDL10 - - - - 2.03 2.56 1.09 - -

Mammary cancer Highest BMDL10 - - - - - - - 0.77
Lowest BMDL10 - - - - - - - - 0.55

Leukemia Highest BMDL10 - - - - - - - 0.95 2.01
Lowest BMDL10 - - - - - - - 0.48 1.28

Colon cancer Highest BMDL10 - - - - - - - 1.91 2.90
Lowest BMDL10 - - - - - - - 0.96 0.82

Notes: M = male; F = female;

a

Wang & Busby (30);

b

Aaslyng et al. (16);

c

Kushida et al. (29);

d

Carthew et al. (28)