Table 3.
MIC distribution of macrolide antibiotic based on the presence of macrolide resistance determinant (n = 113)
| Antimicrobial agent | MIC (μg/mL) distribution | MIC range | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||||||||
| 0.032 | 0.125 | 0.25 | 0.5 | 0.75 | 1 | 2 | 3 | 4 | 6 | 8 | 12 | 16 | 24 | 32 | 48 | 96 | > 256 | ||
| Erythromycina | |||||||||||||||||||
| erm(B) | 1 | 5 | 16–> 256 | ||||||||||||||||
| mef(A) | 1 | 3 | 1 | 1 | 2 | 1 | 3 | 5 | 1 | 1 | 1 | 0.032–> 32 | |||||||
| erm(B) + mef(A) | 1 | 4 | 2–> 256 | ||||||||||||||||
| Azithromycinb | |||||||||||||||||||
| erm(B) | 1 | 5 | 1–> 256 | ||||||||||||||||
| mef(A) | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 2 | 1 | 1 | 1 | 3 | 1 | 0.125–> 256 | ||||
| erm(B) + mef(A) | 1 | 4 | 8–> 256 | ||||||||||||||||
Notes:
a
Resistance to erythromycin was defined as MIC ≥ 1 μg/mL;
b
Resistance to azithromycin was defined as MIC ≥ 2 μg/mL