Table 2.
Odds of incident diabetes at 5 years by measured and predicted values for intrahepatic fat and visceral fata.
| Oddsb of Incident Diabetes, Odds Ratio [95% CI] | ||||||
|---|---|---|---|---|---|---|
| Unadjusted | P value | Model 1c | P value | Model 2d | P value | |
| Hepatic fat, measured by CT or metabolite score | ||||||
| Intrahepatic fata | 1.61 [1.23, 2.10] | 4.48e−04 | 1.65 [1.25, 2.16] | 3.26e−04 | 1.53 [1.13, 2.10] | 6.71e−03 |
| MET-Liver | 1.91 [1.38, 2.65] | 1.1e−04 | 2.04 [1.46, 2.86] | 3.33e−05 | 2.04 [1.37, 3.03] | 3.91e−04 |
| Visceral fat, measured by CT or metabolite score | ||||||
| Visceral fat | 1.76 [1.36, 2.27] | 1.76e−05 | 1.86 [1.39, 2.48] | 2.44e−05 | 1.98 [1.26, 3.11] | 3.18e−03 |
| MET-Visc | 2.23 [1.52, 3.25] | 3.46e−05 | 2.43 [1.67, 3.55] | 4.25e−06 | 2.80 [1.75, 4.46] | 1.53e−05 |
| Metabolite-derived adiposity scores adjusted for CT-measured adiposity | ||||||
| MET-Liver, adjusted for Intrahepatic fat | – | – | – | – | 1.87 [1.06, 3.27] | 0.03 |
| MET-Visc, adjusted for visceral fat | – | – | – | – | 2.38 [1.34, 4.25] | 3.20e−03 |
| Measured visceral fat area adjusted for hepatic attenuation | ||||||
| Intrahepatic fat | – | – | – | – | 1.36 [0.97, 1.92] | 0.08 |
| Visceral fat | – | – | – | – | 1.78 [1.08, 2.93] | 0.02 |
aInverse hepatic attenuation in Hounsfield units (HU*-1) visceral fat area (cm2).
bOR by z-score of inverse hepatic attenuation or visceral fat area (cm2).
cAdjusted for age, gender, study site.
dModel 1 + adjustment for BMI (kg/m2), energy intake (kCal/day), Alternative Health Eating Index-2010 (AHEI-2010), physical activity (MET-minutes/week), use of lipid-lowering medications.