. Author manuscript; available in PMC: 2024 Apr 30.

Published in final edited form as: Anticancer Res. 2019 Aug;39(8):4065–4071. doi: 10.21873/anticanres.13563

Table I.

Comparison between serosal surface implantation (SSI) and the tumor-sealing method (TSM) for surgical orthotopic implantation (SOI) of colon cancer in a nude mouse model.

Timing		SSI (n=15)	TSM (n=15)	p-Value
Day 20	Tumor volume (mm³)	258.1±227.0	262.3±211.7	0.960
	PC (%)	12 (80)	3 (20)	0.001
	PC grade 0/I/II/III (%)	3/7/2/3 (20/46.7/13.3/20)	12/3/0/0 (80/20/0/0)	0.002
Necropsy	Necropsy day	53.0±20.9	56.5±14.5	0.661
	Tumor volume (mm³)	1289.9±631.0	1618.1±1507.4	0.537
	PC,n (%)	10/12 (83.3)	8/10 (80)	0.840
	Liver metastasis (%)	5/12 (41.7)	5/10 (50)	0.696
	Lung metastasis (%)	0/12 (0)	1/10 (10)	0.201

Peritoneal Carcinomatosis (PC) grade: 0: No seeding nodules; 1: 1–15 seeding nodules; 2: 16–99 seeding nodules; 3: >100 seeding nodules.