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. 2024 Apr 29;14:9824. doi: 10.1038/s41598-024-60441-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of FADD inhibited the progression and enhanced susceptibility to 5-FU of HNSCC cell. (A,B) Line diagram displaying the role of FADD knockdown in HNSCC cells proliferation and susceptibility to 5-FU. Student’s T test (SCC15 p = 0.0059; SCC9 p = 0.0048) and Two-way ANOVA (SCC15 siNC vs. siFADD p < 0.0001, siNC vs. siNC + 5-FU p < 0.0001, siFADD vs. siFADD + 5-FU p < 0.0001, siNC + 5-FU vs. siFADD + 5-FU p = 0.001; SCC9 siNC vs. siFADD p < 0.0001, siNC vs. siNC + 5-FU p < 0.0001, siFADD vs. siFADD + 5-FU p < 0.0001, siNC + 5-FU vs. siFADD + 5-FU p < 0.0001) were used to statistically test the efficiency of FADD knockdown and cell proliferation assays, respectively. (C,D) Transwell assay showing the contribution of FADD in HNSCC cell migration and invasion ability after downregulation of FADD. (SCC15 Migration p = 0.0037, Invasion p = 0.0005; SCC9 Migration p = 0.0015, Invasion p = 0.0037). Student’s T test was used to conduct statistical tests for migration and invasion ability.