Table 4.

Summary of calculation of ADME results for selected Limonene derivatives.

S/N.	Absorption			Distribution		Metabolism		Excretion
	Water solubility Log S	Caco-2 ppermeability (10–6 cm/s)	Intestinal absorption (human) %	VDss (human) (log L/kg)	B.B.B permeability	CYP450 1A2 inhibitor	CYP450 2C9 Inhibitor	Total clearance (ml/min/kg)	Renal OCT2 substrate
01	− 3.568	1.403	95.898	0.396	Yes	No	No	0.214	No
02	− 5.546	1.560	95.125	0.92	No	Yes	No	0.187	No
03	− 2.252	1.719	100	− 1.411	Yes	No	No	0.643	No
04	− 2.683	1.312	100	− 1.602	Yes	No	No	− 0.003	Yes
05	− 2.656	1.263	100	0.039	Yes	No	No	− 17.034	No
06	− 5.502	1.527	95.883	0.906	Yes	Yes	No	0.314	No