Fig. 6.

Anticancer Mechanism of nutmeg seed through Apoptotic Pathways. Nutmeg inhibited melanoma cells B16-F10, oral cavity KB cell lines, and lung cancer NCI-H187 cell lines, and apoptosis via caspase-3. Induced apoptosis in Jurkat cell proliferation significantly and human leukemia cell line through Sirtuin-1 (SIRTI) mRNA downregulation pathway. Nutmeg inhibited breast cancer MCF7 cell lines and human colorectal cancer cells HCT 116 through angiogenesis pathway. Nutmeg inhibited leukemia K562 through DNA damage response pathways and the mitochondrial pathway. It also induced hepato-protectivity, through inhibiting Tumor necrosis factor-alpha (TNF- α) which is released from macrophages that lead to the suppression of apoptosis. Nutmeg induced cytotoxicity against human neuroblastoma cells SK-N-SH by apoptotic mechanism.