Fig. 7.

Psychotropic mechanisms of action and narcotic effects of nutmeg seed. Nutmeg stimulates the release of serotonin that creates a feeling of relaxation or sedation. This mechanism is triggered by the nutmeg interaction with the endocannabinoid system in the brain. Nutmeg extract inhibited the and monoacylglycerol lipase (MAGL) and the endocannabinoid catabolizing enzymes fatty acid amide hydrolase, The inhibition of MAGL stimulates the anti-nociceptive, anxiolytic, and anti-emetic responses, elevate brain levels precursor of inflammatory mediators, resulting in the reduction of neuroinflammation.