Characterization of blank and drug-loaded NPs fabricated using flash nanoprecipitation in THF or DMF, respectively, from: (A) P(L)LA10K-b-PEG10K (B) P(L)LA10K-b-POEGMA47510K (C) P(L)LA10K-b-POEGMA200010K.
| Solvent | Polymer | Hydrodynamic diameter (nm) | Polydispersity | Zeta potential (mV) | Drug loading capacity (%) | Encapsulation efficiency (%) |
|---|---|---|---|---|---|---|
| THF | P(L)LA10K-b-PEG10K | 159 ± 2 | 0.34 | −4 ± 1 | — | — |
| P(L)LA10K-b-POEGMA47510K | 88 ± 2 | 0.27 | −15 ± 2 | — | — | |
| P(L)LA10K-b-POEGMA200010K | 114 ± 1 | 0.21 | −11 ± 1 | — | — | |
| DMF | P(L)LA10K-b-PEG10K | 151 ± 1 | 0.29 | −1 ± 1 | — | — |
| P(L)LA10K-b-POEGMA47510K | 43 ± 1 | 0.28 | −1 ± 1 | — | — | |
| P(L)LA10K-b-POEGMA200010K | 81 ± 3 | 0.39 | −1 ± 1 | — | — | |
| DMF + 1 mg mL−1 Dox·HCl) | P(L)LA10K-b-PEG10K | 343 ± 3 | 0.25 | 1 ± 2 | 3.3 ± 0.1 | 33 ± 1 |
| P(L)LA10K-b-POEGMA47510K | 97 ± 3 | 0.33 | 1 ± 4 | 2.5 ± 0.1 | 25 ± 1 | |
| P(L)LA10K-b-POEGMA200010K | 102 ± 5 | 0.37 | 1 ± 1 | 1.4 ± 0.2 | 14 ± 2 |