Table 3.
Main characteristic of the eligible studies for the periodontitis treatment and dyslipidemia
| Author, year | Country | Study design | Sample size (treat / control) | Diagnosis criteria for periodontitis | Mean age (year) | Age ratio (treat: control) | % Males | Male ratio (treat: control) | Therapeutic Schedule | Dyslipidemia diagnosis (any of the following indicators, mg/dl) | Lipids index | Effect index | Matching or correction factor | Quality |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Duan JY, 2009 [67] | China | Cohort (prospective) | 20 | Secure | 55.60 | NI | 55 | NI | Initial therapy | TC > 220; TG > 150; HDL < 35; LDL > 140 | TC, TG, LDL, HDL | Mean (SD) | – | High |
| Fentoglu O, 2010 [68] | Turkey | Cohort (prospective) | 20 | Insecure | 51.85 | NI | 40 | NI | Initial therapy | TG > 200; TC > 200; LDL > 130; HDL < 35; VLDL > 40 | TG, TC, LDL, HDL | Mean (SD) | – | High |
| Fu YW, 2016 [69] | Chnia | RCT | 54/55 | Secure | 46.93 | 0.99 | Treat group: Initial therapy; Control group: supragingival scaling | TG > 20; HDL < 40; LDL > 160 | TC, TG, LDL, HDL | Mean (SD) | – | High risk of bias | ||
| Losche W, 2005 [70] | Germany | Cohort (prospective) | 32 | NI | 42.80 | NI | 53.13 | NI | Initial therapy | NI | TC, TG, LDL, HDL | Mean (SD) | – | Moderate |
| Macovei-Surdu A, 2013 [71] | Romania | Cohort (prospective) | 30/30 | Insecure | 39.53 | 0.96 | 60 | 1.36 | Treat group: Initial therapy: Control group: oral hygiene maintenance measures | NI | TC, TG, LDL, HDL | Mean | – | Moderate |
| Nassar PO, 2012 [72] | Brazil | RCT | 10/10 | Secure | NI | NI | NI | NI | Treat group: Initial therapy, Maintenance therapy: Control group: Initial therapy | NI | TC, TG | Mean (SD) | – | Unclear risk of bias |
| Nibali L, 2015 [101] | United Kingdom | Cohort (prospective) | 12 | Secure | NI | NI | NI | NI | Initial therapy, open flap debridement | LDL, HDL, IDL, VLDL | Mean (SD) | Age, gender and number of teeth | High | |
| Nicolaiciuc O, 2016 [74] | Romania | Cohort (prospective) | 20 | Insecure | 49.55 | NI | 40 | NI | Initial therapy | TG > 200; TC > 200; LDL > 130; HDL < 35; VLDL > 40 | TG, TC, LDL, HDL, VLDL | Mean (SD) | – | Moderate |
| Oz SG, 2007 [75] | Turkey | RCT | 25/25 | Insecure | 50.34 | 0.95 | 38 | 1.11 | Treat group: Initial therapy: Control group: without applying periodontal treatment | TC>200; LDL>130; HDL<35; VLDL> 40; TG>200 | TG, TC, LDL, HDL, VLDL | Mean (SD) | – | Unclear risk of bias |
| Tawfig A, 2015 [76] | Saudi Arabia | RCT | 15/15 | Insecure | NI | NI | 63.33 | 1.38 | Treat group: Initial therapy, oral hygiene instructions, Control group: oral hygiene instructions | TC ≥200; LDL ≥130; HDL ≤35; TG ≥150 | TC, TG, LDL, HDL | Mean (SD) | – | Unclear risk of bias |
| Zuza EP, 2016 [77] | Brazil | Cohort (prospective) | 54 | Secure | 44.26 | NI | 25.93 | NI | Initial therapy | NI | TC, TG, LDL, HDL | Mean (SD) | – | High |
| Abhay Pandurang Kolte, 2022 [78] | India | Intervention trial | 60 | Secure | NI | NI | 36.67 | NI | Non-surgical periodontal treatment | NI | TC, TG, LDL, HDL | Mean (SD) | – | – |
Initial therapy: supragingival scaling, subgingival scaling and root planning
Abbreviation: RCT randomised clinical trial, TC total cholesterol, TG triglyceride, LDL low density lipoprotein cholesterol, HDL high density lipoprotein cholesterol, VLDL very low density lipoprotein cholesterol, NI not informed, SD standard error